Prof. Dr. Doris Heinrich

dhDoris Heinrich joined the Leiden Institute of Physics in 2013. Her research focus lies on the biophysics of living cell dynamics. Investigated systems include molecular motors in vivo, external stimuli leading to cell signalling, cell adhesion dynamics and lipid membrane organisation.
Doris graduated with a Master's in Physics (Topic: Near-field Scanning Optical Microscopy of Semiconductor Nanostructures) from the University of Texas at Austin/ USA.
She received her Ph.D. in Semiconductor Physics (Topic: Optically Induced Charge Storage in Self-assembled Semiconductor Quantum Dots) from the Technische Universität München. Then, she performed her postdoctoral research in Munich, Los Angeles and Heidelberg with Prof. Dr. E. Sackmann, investigating the mechanical properties of the microtubule/actin cross-talk of living cells.
Afterwards, she worked as a Business Consultant with McKinsey & Company on several projects in France, the Near-Middle East and the USA. In 2007, she started her own research group at the Ludwig-Maximilians-University Munich (LMU). Since February of 2013, she is Professor at Leiden University (NL) and Head of Fraunhofer Attract Group at the Fraunhofer ISC in Würzburg (Germany).

 

Visit the Heinrich group homepage

 

Professional and Scientific Experience

since 2013:
 
 
 
2007-2013:
Professor of Biophysics at Leiden University, LION, Institute of Physics, and
Head of Fraunhofer Attract Group "3D NanoCell" at the Fraunhofer ISC, Würzburg, Germany
Cell Biophysics Group-Leader at the LMU  Munich, Germany
2006-2007:
Business Consultant with McKinsey & Company
2003-2005:
Postdoc in Biophysics at TU Munich, Uni Heidelberg and UCLA, USA
April 2003:
Ph.D. (Dr. rer. nat.) in Semiconductor Physics at TU Munich (WSI), Germany

 

Prizes, Awards, Fellowships

2013
Fraunhofer Attract Grant
2011
2007
CeNS Publication Award
Science Career Fellowship
2004 - 2005 Academics&Science Program (HWP II) Postdoc Fellowship
2004 BaCaTec Visiting Fellowship Grant
2004 Minerva Foundation Grant
2002 Academics & Science Program (HWP I) Doctoral Fellowship
1997 Honor Society Membership of "Phi Kappa Phi" (Austin, TX /USA) due to GPA of 4.0
1995 German Academic Exchange Program (DAAD) Fellowship for studies in the USA

 

 

Scientific Publications (peer-reviewed)

  • Distinct cell shapes determine accurate chemotaxis
    L. Tweedy , B. Meier, J. Stephan, D. Heinrich, and R. G. Endres,                          Scientific Reports (accepted 2013)

     

  • Three-dimensional single-particle tracking in live cells: news from the third dimension    A. Dupont, M. Gorelashvili, V. Schüller, F. Wehnekamp, D. Arcizet, Y. Katayama, D.C. Lamb, and D. Heinrich,

      New J. Phys. 15, 075008 (2013)

 

  • Distribution of diffusion measures from a local mean-square displacement analysis

A. Nandi, D. Heinrich, and B. Lindner
Phys. Rev. E 86, 021926 (2012)

 

  • Local Motion Analysis Reveals Impact of the Dynamic Cytoskeleton on Intracellular Sub-Diffusion

M. Otten, A. Nandi, D. Arcizet, M. Gorelashvili, B. Lindner and D. Heinrich
Biophysical Journal 102:758-767 (2012)

 

  • Contact-controlled amoeboid motility induces dynamic cell trapping in 3D-microstructured surfaces

D. Arcizet, S. Capito, M. Gorelashvili, C. Leonhard, M. Vollmer, S. Youssef, S. Rappl and D. Heinrich
Soft Matter 8(5):1473-1481 (2012)

 

  • Chemotactic cell trapping in controlled alternating gradient fields

B. Meier, A. Zielinski, C. Weber, D. Arcizet, S. Youssef, T. Franosch, J. O. Rädler, and D. Heinrich
Proc. Natl. Acad. Sci. 108(28):11417-11422 (2011)

 

  • Physics of cellular movements

E. Sackmann, F. Keber and D. Heinrich
Annu. Rev. Condens. Matter Phys. 1:257–76 (2010)

 

  • Probing GFP-actin diffusion in living cells using Fluorescence Correlation Spectroscopy

H. Engelke, D. Heinrich and J.O. Rädler
Phys. Biol.7(4):046014 (2010)

 

  • Axonal Guidance by Surface Microstructuring for Intracellular Transport Investigations

C. Pelzl, D. Arcizet, G. Piontek, J. Schlegel, and D. Heinrich
ChemPhysChem 10, 2884 (2009)

 

  • Impact of external stimuli and cell micro-architecture on intracellular transport states

J. Mahowald, D. Arcizet, and D. Heinrich
ChemPhysChem 10, 1559 (2009)

 

  • Temporal analysis of active and passive transport in living cells

D. Arcizet, B. Meier, E. Sackmann, J. Rädler, and D. Heinrich
Phys. Rev. Lett. 101, 248103 (2008)

 

  • Temporal analysis of active and passive transport in living cells

D. Arcizet, B. Meier, E. Sackmann, J. Rädler, and D. Heinrich
Virtual Journal of Biological Physics Research, published on December 15 (2008)

 

  • Actin-Cytoskeleton Dynamics in Non-monotonic Cell Spreading

D. Heinrich, S. Youssef, B. Schroth-Diez, U. Engel, D. Aydin, J. Blümmel, J. Spatz, and G. Gerisch
Cell Adhesion & Migration 2, issue 2, p. 58-68 (April/May/June 2008) and Cover Image

 

  • Active mechanical stabilization of the viscoplastic intracellular space of Dictyostelia cells by microtubule-actin crosstalk

D. Heinrich, E. Sackmann
Acta Biomaterialia 2, p. 619-631 (May 2006)

 

  • Micromechanics of Cells: Viscoelastic Microscopy of Cells

E. Sackmann, A. Reuther, and D. Heinrich
Mechanics of the 21st Century - Eds.: W. Gutkovski, and T. Kowalevski, Springer Verlag, Dordrecht (Netherlands),
ISBN-10 1-4020-3456-3, p. 313-328 (2005)

and Proceedings (2004)

 

  • Wavelength Selective Optically Induced Charge Storage in Self-asssembled Semiconductor Quantum Dots

Doris Heinrich
Selected Topics of Semiconductor Physics and Technology, Eds.: G. Abstreiter, M.-C. Amann, M. Stutzmann, P. Vogl
ISBN 3-932749-52-9 (July 2003)

 

  • Optical Charging and De-charging of InAs Quantum Dots

D. Heinrich, A. Zrenner, G. Böhm, and G. Abstreiter
The Physics of Semiconductors, World Scientific © 2001
ISBN: 981-02-4030-9 (CD), section: L 1 article: 4

 

  • Charging Dynamics of Self- Assembled InAs Quantum Dots Investigated by Wavelength Selective Optically Induced Charge Storage Measurements

D. Heinrich, J. Hoffmann, A. Zrenner, G. Böhm, and G. Abstreiter
Physica Status Solidi (b) 224,1 p.357 (March 2001)

 

  • Optically-induced charge storage in self-assembled InAs quantum dots

D. Heinrich, J. Hoffmann, J. J. Finley, A. Zrenner, G. Böhm, G. Abstreiter
Thin Solid Films 380, p. 192 (December 2000)

 

  • Optical charging of self-assembled InAs quantum dots

D. Heinrich, J. Finley, M. Skalitz, J. Hoffmann, A. Zrenner, G. Böhm, G. Abstreiter
Optical Properties of Semiconductor Nanostructures, Eds.: M.L. Sadowski, M. Potemski, and M. Grynberg, Kluwer Academic Publishers, Dordrecht, ISBN: 0-7923-6316-7, p. 365-377 (June 2000)

 

  • Electron and hole storage in self-assembled InAs quantum dots

D. Heinrich, J. Hoffmann, J. J. Finley, A. Zrenner, G. Böhm, G. Abstreiter
Physica E7, p. 484-488 (May 2000)

 

  • Electrical detection of charge storage in self-assembled InAs quantum dots

J. J. Finley, M. Skalitz, D. Heinrich, M. Arzberger, A. Zrenner, G. Böhm, and G. Abstreiter
The Physics of Semiconductors, World Scientific, Singapore © 1999

section: X B, article: 1, ISBN: 981-02-4030-9 (CD), p. 1138

 

  • Exciton transport into single quantum wires studied by time-resolved low-temperature near-field scanning optical microscopy

Ch. Lienau, A. Richter, D. Heinrich, M. Süptitz, T. Elsaesser, R. Nötzel, M. Ramsteiner, and K. H. Ploog
The Physics of Semiconductors, World Scientific, Singapore © 1999
section: VII B, article: 21, ISBN: 981-02-4030-9 (CD), p. 1435

 

  • Time-resolved near-field spectroscopy of the carrier dynamics in single GaAs nanostructures

Ch. Lienau, A. Richter, D. Heinrich, T. Elsaesser, M. Ramsteiner, R. Nötzel, and K. H. Ploog
Ultrafast Phenomena XI, Springer Series in Chemical Physics, Eds.: T. Elsaesser, J.G. Fujimoto, D. A. Wiersma, W. Zinth,
Springer Verlag, Berlin, ISBN: 3540654305, p. 168-170 (December 1998)

 

  • Exciton transport into a single quantum wire studied by picosecond near-field optical spectroscopy

A. Richter, M. Süptitz, D. Heinrich, Ch. Lienau, T. Elsaesser, M. Ramsteiner, R. Nötzel, and K. H. Ploog
Appl. Phys. Lett. 73,15 p. 2176 (October 1998)

 

  • Nanoscale mapping of confinement potentials in single semiconductor quantum wires by near-field spectroscopy

Ch. Lienau, A. Richter, G. Behme, M. Süptitz, D. Heinrich, Ch. Lienau, T. Elsaesser, M. Ramsteiner, R. Nötzel, and K. H. Ploog,
Phys. Rev. B58, 4 p. 2045 (July 1998)

 

Books

  • Wavelength Selective Optically Induced Charge Storage in Self-asssembled Semiconductor Quantum Dots

Doris Heinrich,
Selected Topics of Semiconductor Physics and Technology, Eds.: G. Abstreiter, M.-C. Amann, M. Stutzmann, P. Vogl, ISBN 3-932749-52-9 (July 2003)

 

Conference Proceedings

  • Micromechanics of Cells: Viscoelastic Microscopy of Cells

E. Sackmann, A. Reuther, and D. Heinrich
21st International Congress of Theoretical and Applied Mechanics (ICTAM’04), Warsaw, Poland, Abstracts Books and CD- ROM Proceedings, Eds.: W. Gutkowski, and T. Kowalevski, ISBN: 83-89687-011, IPPT-PAN- Verlag, Warsaw (2004)

 

  • Optically induced charge storage and de-charging in InAs quantum dots

D. Heinrich, A. Zrenner, G. Böhm, and G. Abstreiter
Proc. of the 25th Int. Conference on the Physics of Semiconductors, Osaka
Springer Proc. 87, Eds.: N. Miura and T. Ando, Springer Verlag, p. 1115, Berlin (2001)

 

Annual Reports

  • In(Ga)As quantum dots as wavelength selective storage media

D. Heinrich, M. Kroutvar, A. Zrenner, G. Böhm, M. Bichler and G. Abstreiter
Fundamental research in semiconductor electronics-Annual Report 2001,
Walter Schottky Institut (TUM), p.80 (2002)

 

  • Optically induced charge storage and de-charging in InAs quantum dots

D. Heinrich, A. Zrenner, G. Böhm, and G. Abstreiter
Fundamental research in semiconductor electronics - Annual Report 2000,
Walter Schottky Institut (TUM), p.76 (2001)

 

  • Wavelength Selective Optically Induced Charge Storage in InAs Quantum Dots

D. Heinrich, J. Hoffmann, A. Zrenner, G. Böhm, and G. Abstreiter
Fundamental research in semiconductor electronics - Annual Report 1999,
Walter Schottky Institut (TUM), p.60 (2000)

 

  • Electron and Hole Storage in self-assembled quantum dots

D. Heinrich, J. Finley, R. Griesmeier, J. Hoffmann, C. Miesner, R. Neumann, G. Böhm, A. Zrenner, K. Brunner, and G. Abstreiter,
Fundamental research in semiconductor electronics - Annual Report 1998,
Walter Schottky Institut (TUM), p.50 (1999)

 

Selected Invited Talks

  • Controlling Cell Migration by External Stimuli

D. Heinrich
International Workshop “Cancer Cells On-Chip” June 2012, University of Lyon, France

 

  • Motion States in Intracellular Transport

D. Heinrich

Topical Talk at the DPG-Springmeeting (Deutsche Physikalische Gesellschaft) 2011, Dresden, Germany

 

  • Spatio-Temporally Controlled Cell Migration

D. Heinrich
Eugene-Wigner-Colloquium des Graduiertenkolleg 1558 und des SFB 910, 2011, Berlin, Germany

 

  • Physics in Living Cells: Intracellular Transport and Cellular Migration

D. Heinrich
Physikerinnentagung of the Deutsche Physikalische Gesellschaft, 2010, Munich, Germany

 

  • Dynamic Properties of the Micro- and Nano-Architecture in Living Cells (Invited Talk)

D. Heinrich
Nanosystems and Sensors - Winterschool 2009, St. Anton, Austria


Teaching

  • 2013 at Leiden University, LION, Leiden Institute of Physics

        Lecture Phyiscs of Life Processes 2

       Lecture Advanced Biophysics

  • SS 2012 at the LMU München

Hauptseminar Physics of Structure and Function ofLiving Cells
Seminar and Journal Club Biophysics and Cell Dynamics

  • WS 2011/2012 at the LMU München

Lecture Dynamic Nano- and Miroarchitecture in Living Cells (Univ. Leipzig)
Hauptseminar Physik der dynamischen Prozesse in lebenden Zellen
Seminar and Journal Club Biophysics and Cell Dynamics

  • SS 2011 at the LMU München

Hauptseminar Selbstorganisation und Morphogenese
Seminar and Journal Club Biophysics and Cell Dynamics
Seminar Soft Matter and Biophysics

  • WS 2010/2011 at the LMU München

Hauptseminar Selbstorganisation und Morphogenese
Seminar and Journal Club Biophysics and Cell Dynamics
Seminar Soft Matter and Biophysics

  • SS 2010 at the LMU München

Lehrstuhlseminar Physik kondensierter Materie
Seminar and Journal Club Biophysics and Cell Dynamics
Seminar Soft Matter and Biophysics

  • WS 2009/2010 at the LMU München

Hauptseminar Biophysik der Moleküle
Seminar and Journal Club Biophysics and Cell Dynamics
Seminar Soft Matter and Biophysics

  • SS 2009 at the LMU München

Hauptseminar Biophysik der Zelle
Seminar and Journal Club Biophysics and Cell Dynamics
Seminar Soft Matter and Biophysics

  • WS 2008/2009 at the LMU München

Übungsleitung Experimantalphysik E1: Mechanik
Seminar and Journal Club Biophysics and Cell Dynamics
Seminar Soft Matter and Biophysics

  • SS 2008 at the LMU München

Hauptseminar Biophysik der Zelle
Seminar and Journal Club Biophysics and Cell Dynamics

  • WS 2007/2008 at the LMU München

Hauptseminar Biophysik der Systeme
Seminar Soft Matter and Biophysics

  • SS 2007 at the LMU München

Übungsleitung Vorlesung: Physik für Pharamzeuten

  • SS 2004 at the TU München

Praktikum Biophysik - Aktin Polymerisations Versuch

  • WS 2003/2004 at the TU München

Praktikum Biophysik - Optik Versuch

  • SS 2003 at the TU München

Praktikum Biophysik für Biochemiker - Aktin Polymerisations Versuch

  • SS 2002 at the TU München

Praktikum Biophysik für Biochemiker - Optik Versuch

  • SS 2001 at the TU München

Übung Einführung in die Physik II (in English)

  • WS 2000/2001 at the TU München

Übung Einführung in die Physik I

  • SS 2000 at the TU München

Praktikum Physik für Maschinenbaustudenten - Optik Versuch

  • WS 1999/2000 at the TU München

Übung Festkörperphysik I

  • WS 1998/1999 at the TU München

Übung Festkörperphysik I (in English)

  • SS 1997 at the University of Texas at Austin

Teaching assistant

 

International conferences (Oral Presentations)

  • Probing PI3-Kinase based feedback in alternating chemotactic gradient fields with ongoing cell starvation time

D. Heinrich
Annual International Dictyostelium Conference (DICTY 2012) 2012, Madrid, Spain

  • Spatio-temporally controlled actin polymerisation and pattern formation in living cells

D. Heinrich
CellMech – Cell Mechanics Meeting 2011, Amsterdam, Netherlands

  • Spatio-temporally alternating gradient fields for chemotactic cell control

D. Heinrich
Gordon Conference on “Gradient sensing and directed cell migration” 2011, Les Diablerets, Switzerland

  • Cell motility in surface-structured environments

D. Heinrich
International Dictyostelium Conference (DICTY 2010) 2010, Cardiff, UK

  • Intracellular transport phenomena influenced by micro- and nanoarchitecture of living cells

D. Heinrich
Physics of the Cell: from the edge to the heart (PhysCell2009) 2009, Primosten, Croatia

  • Cell Spreading Dynamics: Actin Cortex Fluctuations and Plasma Membrane Demixing- and Pearling-Effects in the Absence of F-Actin

D. Heinrich, and G. Gerisch
The American Society for Cell Biology Annual Meeting 2008, San Francisco, USA

  • Actin-microtubule crosstalk in the viscoplastic intracellular space and sub-second actin dynamics during cell spreading

D. Heinrich, E. Sackmann and G. Gerisch
International Dictyostelium Conference DICTY 2007, Rotenburg, Germany

  • Intracellular Transport: A Levy Flight Process with a Log-Normal Velocity Distributions

E. Sackmann and D. Heinrich
69th Annual Meeting of the Deutsche Physikalische Gesellschaft (DPG) in the World Year of Physics 2005, Berlin, Germany

  • Micromechanics of Cells: Viscoelastic Microscopy of Cells

E. Sackmann, A. Reuther, and D. Heinrich
21st International Congress of Theoretical and Applied Mechanics ICTAM’04, Warsaw, Poland

  • Viscoelastic Mapping of Living Cell Interiors

D. Heinrich, E. Sackmann, J. Köhler, G. Gerisch
Minerva Gentner Symposium on Biomaterials and Soft Matter 2004, Max-Planck-Gesellschaft, Dead Sea, Israel

  • Functional Micro-Domains of Glycolipids with Partially Fluorinated Membrane Anchors Impact on Cell Adhesion

D. Heinrich, M. Schneider, L. Limozin, and M. Tanaka
Annual American Physical Society (APS) March Meeting 2004, Montreal, Canada

  • Viscoelastic Mapping of Living Cell Interior

D. Heinrich, and E. Sackmann
Annual American Physical Society (APS) March Meeting 2004, Montreal, Canada

  • Optische Ladungsspeicherung und Auslesen in selbstorganisierten In(Ga)As Quantenpunkten

D. Heinrich, M. Kroutvar, A. Zrenner, G. Böhm, M. Bichler und G. Abstreiter
65. Frühjahrstagung der Deutschen Physikalischen Gesellschaft (DPG) 2001, Hamburg, Germany

  • Optically induced charge storage and de-charging in InAs quantum dots

D. Heinrich, A. Zrenner, G. Böhm, and G. Abstreiter

25th International Conference on the Physics of Semiconductors (ICPS 2000), Osaka, Japan

  • Charging Dynamics of Self- Assembled InAs Quantum Dots Investigated by Wavelength Selective Optically Induced Charge Storage Measurements

D. Heinrich, J. Hoffmann, A. Zrenner, G. Böhm, and G. Abstreiter
International Conference on Semiconductor Quantum Dots (QD 2000), Munich, Germany

  • Optically-induced charge storage in self-assembled InAs quantum dots

D. Heinrich, J. Hoffmann, J. J. Finley, A. Zrenner, G. Böhm, G. Abstreiter
E-MRS Spring Symposium 2000, Strassbourg, France

  • Optical charging of self-assembled InAs quantum dots

D. Heinrich, J. Finley, M. Skalitz, J. Hoffmann, A. Zrenner, G. Böhm, G. Abstreiter
NATO Advanced Research Workshop 1999, Jaszowiec, Poland

  • Electron and hole storage in self-assembled InAs quantum dots

D. Heinrich, J. Hoffmann, J. J. Finley, A. Zrenner, G. Böhm, G. Abstreiter
The 9th International Conference on Modulated Semiconductor Structures 1999, Fukuoka, Japan

  • Electron and hole storage in self-assembled InAs quantum dots

D. Heinrich, J. Hoffmann, J. J. Finley, A. Zrenner, G. Böhm, G. Abstreiter
41st TMS 1999 Electronics Materials Conference (EMC) 1999, Santa Barbara, USA

  • Electrical detection of charge storage in self-assembled InAs quantum dots

J. J. Finley, M. Skalitz, D. Heinrich, M. Arzberger, A. Zrenner, G. Böhm, and G. Abstreiter
24th International Conference on the Physics of Semiconductors (ICPS) 1998, Jerusalem, Israel

  • Exciton transport into single quantum wires studied by time-resolved low-temperature near-field scanning optical microscopy

Ch. Lienau, A. Richter, D. Heinrich, M. Süptitz, T. Elsaesser, R. Nötzel, M. Ramsteiner, and K. H. Ploog
24th International Conference on the Physics of Semiconductors (ICPS) 1998, Jerusalem, Israel

  • Time-resolved near-field spectroscopy of the carrier dynamics in single GaAs nanostructures

Ch. Lienau, A. Richter, D. Heinrich, T. Elsaesser, M. Ramsteiner, R. Nötzel, and K. H. Ploog
Ultrafast Phenomena XI 1998, Garmisch-Partenkirchen, Germany

  • Low-temperature near-field spectroscopy of single GaAs quantum wires

Ch. Lienau, A. Richter, D. Heinrich, T. Elsaesser, M. Ramsteiner, R. Nötzel, and K. H. Ploog
European Quantum Electronics Conference (EQEC 1998), Glasgow, Scotland

 

Workshops

  • Controlling Cell Migration by External Stimuli (Invited Talk)

D. Heinrich
International Workshop “Cancer Cells On-Chip”, University of Lyon 2012, Lyon, France

  • Evaluation of Multiple Force Probes in Reflection Microscopy

F. Keber, P. Paulitschke, E. Weig, D. Heinrich
1st International Symposium on “Integration of Molecular Components in Functional Macroscopic Systems” 2011, Radebeul/ Dresden, Germany

  • Developing Algorithms for Tracking and Analysing Intracellular Motion (Invited Talk)

D. Heinrich
Molecular Motors, Tracks and Transport 2010, Pondicherry, India

  • The Dynamic Micro- and Nanoarchitecture in Living Cells (Invited Talk)

D. Heinrich
Collective Dynamics and Pattern Formation in Active Matters-International Workshop 2009, Berlin, Germany

  • Dynamic Properties of the Micro- and Nano-Architecture in Living Cells (Invited Talk)

D. Heinrich
Nanosystems and Sensors - Winterschool 2009, St. Anton, Austria

  • Time-resolved Analysis of Active and Passive Noise Spectra in Intracellular Transport (Talk)

D. Heinrich, D. Arcizet, B. Meier, E. Sackmann and J. Rädler
Advances in Single-Molecule Research for Biology & Nanoscience, XI. Annual Linz Winter Workshop 2009, Linz, Austria

  • Temporal Analysis of active and passive transport in living cells (Talk + Poster)

D. Heinrich, D. Arcizet, B. Meier, E. Sackmann and J. Rädler
Complex Nanosystems: Assembly, Control and Functionality 2008, San Servolo, Italy