- In amyloid fibrils, proteins assemble into nanometer-sized columns that have the flexibility of steel. The glue that converts the spaghetti-like proteins to assemble into self-repeating structures that form the fibril are normal inter-protein interaction forces, so the magic lies in the precise arrangement of the protein.
We installed nano-sized markers, measured distances and found - based on gross approximations - a possible arrangement of the fibril for Parkinson's protein alpha-synuclein.
This peek into amyloid structure comes from the Electron Paramagnetic Resonance group of Martina Huber in Leiden in collaboration with the Twente/AMOLF group of Subramaniam.
Read more in Applied Magnetic Resonance
Publ. 27-01-2015 10:53